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ENU Mutagenesis

Balancer Chromosomes

Cre-LoxP Chromosome Engineering

Mutagenesis

1. Establish pedigree from G1 males and females
2. Mate balancer chromosome in G3 pedigrees
3. Screen 500 pedigrees per balancer

Lethal Screen
(Age: 21 days)

Screen for absence of mutant test class of aminals

Viable Screen
(Age: 8 weeks)

Screen all mice (test and carrier class) for
  • Developmental Metabolism
    1. Plasma: Tandem mass spectrometry
    2. Urine: glucose
  • Hematology (CBC)
  • X-ray
    1. Skeleton morphology
    2. Bone density

Phynotype Characterization

  • Morphology
  • Molecular
  • Histopathology
  • Biochemistry
  • Endocrinology

Genomic Mapping

Database, Archiving and Distribution

URL: http://www.mouse-genome.bcm.tmc.edu    Data provided in this web site is only for scientific research and educational purposes. Questions and feedbacks: Webmaster